Research suggests drug treatments could mirror exercise

Researchers from the University of Sydney have revealed a “major breakthrough” which could lead to drug treatments which are able to mirror the health benefits of exercise.

In a report published in the journal Cell Metabolism, the researchers, from the University’s Charles Perkins Centre identified molecular reactions to exercise in the body, providing what has been described as the world's first comprehensive exercise blueprint.

Although the scientists admit that nothing can replace exercise in terms of its health benefits, the breakthrough could help to bring these benefits to people whose condition inhibits their participation in physical activity.

Greater understanding of the bodily processes surrounding physical activity could also help professionals to maximise its effect.

Research Group Head Professor David James explained “exercise is the most powerful therapy for many human diseases, including type 2 diabetes, cardiovascular disease and neurological disorders.

"However, for many people, exercise isn't a viable treatment option. This means it is essential we find ways of developing drugs that mimic the benefits of exercise."

The University of Sydney researchers, in collaboration with researchers from the University of Copenhagen in Denmark, analysed human skeletal muscle biopsies from four untrained, healthy males following 10 minutes of high intensity exercise. Using a technique known as mass spectrometry to study a process called protein phosphorylation, co-author Dr Benjamin Parker discovered that short, intensive exercise triggers more than 1,000 changes.

Most traditional drugs target individual molecules. With this exercise blueprint the scientists say they have proven that any drug that mimics exercise will need to target multiple molecules and possibly even pathways, which are a combination of molecules working together. The majority of changes they discovered have not previously been associated with exercise, with existing research focusing on just a small number of changes.

Report co-author Dr Nolan Hoffman from the Charles Perkins Centre and Faculty of Science added “exercise produces an extremely complex, cascading set of responses within human muscle. It plays an essential role in controlling energy metabolism and insulin sensitivity.

"While scientists have long suspected that exercise causes a complicated series of changes to human muscle, this is the first time we have been able to map exactly what happens.

“Our data clearly show the complexity of the response: it is not one thing, but rather the drug will have to target multiple things. Our research has provided the roadmap to figure this out.”

Click here to view the report, Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates, on the Cell Metabolism website.

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